Design, synthesis, and evaluation of novel fluoroquinolone-flavonoid hybrids as potent antibiotics against drug-resistant microorganisms.

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第一作者： Zhu-Ping,Xiao

第一单位： College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address: xiaozhuping2005@163.com.

作者： Zhu-Ping,Xiao ^[1] ; Xu-Dong,Wang ^[2] ; Peng-Fei,Wang ^[3] ; Yin,Zhou ^[2] ; Jing-Wen,Zhang ^[2] ; Lei,Zhang ^[2] ; Jiao,Zhou ^[2] ; Sha-Sha,Zhou ^[2] ; Hui,Ouyang ^[2] ; Xiao-Yi,Lin ^[2] ; Manzira,Mustapa ^[2] ; Asaimuguli,Reyinbaike ^[2] ; Hai-Liang,Zhu ^[4]

作者单位： College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address: xiaozhuping2005@163.com. ^[1] College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China. ^[2] State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. ^[3] College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address: zhuhl@nju.edu.cn. ^[4]

关键词 DNA gyrase Efflux pump Flavonoid Fluoroquinolone Hybrid Inhibitor