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The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells.

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作者单位: 1] Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. [2] Laboratory for Immune Regulation, Graduate School of Medicine, Chiba University, Chiba, Japan. [3] Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [4] Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan. [5]. [1] 1] Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. [2] Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [3] [4]. [2] Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [3] Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [4] Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [5] 1] Laboratory for Gut Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [2] PRESTO, Japan Science and Technology Agency, Saitama, Japan. [6] Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan. [7] 1] Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. [2] Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [8] 1] PRESTO, Japan Science and Technology Agency, Saitama, Japan. [2] Laboratory for Immune Regeneration, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [9] Department of Gastroenterology, Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba, Japan. [10] Laboratory of Epigenetics, Institute for Protein Research, Osaka University, Osaka, Japan. [11] Laboratory of Cell Engineering, Department of Frontier Research, Kazusa DNA Research Institute, Chiba, Japan. [12] 1] Laboratory for Gut Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [2] CREST, Japan Science and Technology Agency, Saitama, Japan. [13] Laboratory for Immune Homeostasis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [14] 1] Laboratory for Immune Regulation, Graduate School of Medicine, Chiba University, Chiba, Japan. [2] Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan. [3] Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [15] 1] Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. [2] Laboratory for Bioenvironmental Epigenetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan. [3] Graduate School of Medical Life Science, Yokohama City University, Kanagawa, Japan. [4] PRESTO, Japan Science and Technology Agency, Saitama, Japan. [5]. [16]
DOI 10.1038/ni.2886
PMID 24777532
发布时间 2022-04-08
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Nature immunology

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