Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.

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作者： Erchang,Shang ^[1] ; Yiran,Wu ^[2] ; Pei,Liu ^[1] ; Ying,Liu ^[3] ; Wei,Zhu ^[1] ; Xiaobing,Deng ^[4] ; Chong,He ^[1] ; Shan,He ^[1] ; Cong,Li ^[1] ; Luhua,Lai ^[5]

作者单位： BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. ^[1] BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China. ^[2] BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China. Electronic address: liuying@pku.edu.cn. ^[3] Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. ^[4] BNLMS, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. ^[5]

关键词 5-Lipoxygenase Benzo[d]isothiazole 1,1-dioxide Dual functional inhibitor Microsomal prostaglandin E(2) synthase