Antibiotics induce redox-related physiological alterations as part of their lethality.

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第一作者： Daniel J,Dwyer

第一单位： Howard Hughes Medical Institute,Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215;

作者： Daniel J,Dwyer ^[1] ; Peter A,Belenky ^[1] ; Jason H,Yang ^[1] ; I Cody,MacDonald ^[1] ; Jeffrey D,Martell ^[2] ; Noriko,Takahashi ^[3] ; Clement T Y,Chan ^[1] ; Michael A,Lobritz ^[4] ; Dana,Braff ^[1] ; Eric G,Schwarz ^[1] ; Jonathan D,Ye ^[1] ; Mekhala,Pati ^[5] ; Maarten,Vercruysse ^[3] ; Paul S,Ralifo ^[5] ; Kyle R,Allison ^[6] ; Ahmad S,Khalil ^[7] ; Alice Y,Ting ^[2] ; Graham C,Walker ^[3] ; James J,Collins ^[8]

作者单位： Howard Hughes Medical Institute,Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215; ^[1] Departments of Chemistry and. ^[2] Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; ^[3] Howard Hughes Medical Institute,Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215;Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114; ^[4] Chemistry, and. ^[5] Department of Systems Biology, Columbia University, New York, NY 10032; and. ^[6] Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215;Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; ^[7] Howard Hughes Medical Institute,Departments of Biomedical Engineering andCenter of Synthetic Biology, Boston University, Boston, MA 02215;Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;Department of Medicine, Boston University School of Medicine, Boston, MA 02118 jcollins@bu.edu. ^[8]

关键词 DNA repair mutagenesis reactive oxygen species