Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress.

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第一作者： Wenjuan,Li

第一单位： Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China; Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China.

作者： Wenjuan,Li ^[1] ; Weiwei,Wu ^[2] ; Haibo,Song ^[2] ; Fang,Wang ^[2] ; Huanjie,Li ^[2] ; Li,Chen ^[3] ; Yimu,Lai ^[4] ; Joseph S,Janicki ^[5] ; Keith W,Ward ^[6] ; Colin J,Meyer ^[6] ; Xing Li,Wang ^[2] ; Dongqi,Tang ^[7] ; Taixing,Cui ^[8]

作者单位： Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China; Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China. ^[1] Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China. ^[2] Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China. Electronic address: chenli3@medmail.com.cn. ^[3] Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA. ^[4] Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China. ^[5] Department of Pharmacology, Reata Pharmaceuticals, Inc., Irving, TX 75063, USA. ^[6] Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China; Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA. ^[7] Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, China; Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA. Electronic address: Taixing.Cui@uscmed.sc.edu. ^[8]

关键词 Autophagy Diabetes Nrf2 Oxidative stress Ubiquitination β-Cells