首页> PloS one> The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer.

The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer.

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第一作者： Brenda,Cadiz-Rivera

第一单位： Department of Pediatrics, University of Rochester Medical Center and Center for Pediatric Biomedical Research, Rochester, New York, United States of America.

作者： Brenda,Cadiz-Rivera ^[1] ; George,Fromm ^[2] ; Christina,de Vries ^[1] ; Jennifer,Fields ^[3] ; Kathleen E,McGrath ^[1] ; Steven,Fiering ^[3] ; Michael,Bulger ^[1]

作者单位： Department of Pediatrics, University of Rochester Medical Center and Center for Pediatric Biomedical Research, Rochester, New York, United States of America. ^[1] Department of Pediatrics, University of Rochester Medical Center and Center for Pediatric Biomedical Research, Rochester, New York, United States of America; National Institute for Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, United States of America. ^[2] Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America. ^[3]

医学主题词动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);染色质(Chromatin);增强子元件, 遗传学(Enhancer Elements, Genetic);女(雌)性(Female);基因表达调控(Gene Expression Regulation);基因座调控区(Locus Control Region);男(雄)性(Male);小鼠, 129系(Mice, 129 Strain);小鼠, 近交BALB C(Mice, Inbred BALB C);启动区, 遗传(Promoter Regions, Genetic);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);序列缺失(Sequence Deletion);β珠蛋白类(beta-Globins)

DOI 10.1371/journal.pone.0092947

PMID 24817273

发布时间 2021-10-21

基金项目

R01 DK070687/DK/NIDDK NIH HHS/United States T32 GM068411/GM/NIGMS NIH HHS/United States GM068411/GM/NIGMS NIH HHS/United States R01-DK070687-06A1/DK/NIDDK NIH HHS/United States

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