Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway.
第一作者:
Xin-Xiang,Li
第一单位:
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.
作者:
主题词
老年人(Aged);动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞增殖(Cell Proliferation);结肠肿瘤(Colonic Neoplasms);女(雌)性(Female);葡糖醛酸糖苷酶(Glucuronidase);人类(Humans);免疫组织化学(Immunohistochemistry);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);中年人(Middle Aged);肿瘤侵润(Neoplasm Invasiveness);肿瘤分期(Neoplasm Staging);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);受体, IGF1型(Receptor, IGF Type 1);信号传导(Signal Transduction);组织阵列分析(Tissue Array Analysis)
DOI
10.3892/ijo.2014.2430
PMID
24818842
发布时间
2022-04-09
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