Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals.

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作者： M,Arab-Alameddine ^[1] ; R,Lubomirov ^[2] ; A,Fayet-Mello ^[3] ; M,Aouri ^[3] ; M,Rotger ^[2] ; T,Buclin ^[3] ; N,Widmer ^[3] ; M,Gatri ^[1] ; B,Ledergerber ^[4] ; K,Rentsch ^[5] ; M,Cavassini ^[6] ; A,Panchaud ^[1] ; M,Guidi ^[1] ; A,Telenti ^[2] ; L A,Décosterd ^[7] ; C,Csajka ^[8] ; Swiss HIV Cohort Study

作者单位： School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland Division of Clinical Pharmacology, University Hospital Center and University of Lausanne, Lausanne, Switzerland. ^[1] Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland. ^[2] Division of Clinical Pharmacology, University Hospital Center and University of Lausanne, Lausanne, Switzerland. ^[3] Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. ^[4] Clinical Chemistry, University Hospital Basel, Basel, Switzerland. ^[5] Division of Infectious Diseases, University Hospital Center and University of Lausanne, Lausanne, Switzerland. ^[6] Clinical Pharmacology Laboratory, University Hospital and University of Lausanne, Lausanne, Switzerland. ^[7] School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland Division of Clinical Pharmacology, University Hospital Center and University of Lausanne, Lausanne, Switzerland chantal.csajka@chuv.ch. ^[8]

关键词 NONMEM pharmacogenetics simulations