The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain.

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第一作者： Isabel,Cruz-Gallardo

第一单位： Instituto de Bioquímica Vegetal y Fotosíntesis; Centro de Investigaciones Científicas Isla de la Cartuja; Universidad de Sevilla-CSIC; Sevilla, Spain.

作者： Isabel,Cruz-Gallardo ^[1] ; Ángeles,Aroca ^[1] ; Menachem J,Gunzburg ^[2] ; Andrew,Sivakumaran ^[2] ; Je-Hyun,Yoon ^[3] ; Jesús,Angulo ^[4] ; Cecilia,Persson ^[5] ; Myriam,Gorospe ^[3] ; B Göran,Karlsson ^[5] ; Jacqueline A,Wilce ^[2] ; Irene,Díaz-Moreno ^[1]

作者单位： Instituto de Bioquímica Vegetal y Fotosíntesis; Centro de Investigaciones Científicas Isla de la Cartuja; Universidad de Sevilla-CSIC; Sevilla, Spain. ^[1] Department of Biochemistry and Molecular Biology; Monash University; Clayton, Victoria, Australia. ^[2] Laboratory of Genetics; National Institute on Aging-Intramural Research Program; NIH; Baltimore, MD USA. ^[3] Instituto de Investigaciones Químicas; Centro de Investigaciones Científicas Isla de la Cartuja; Universidad de Sevilla-CSIC; Sevilla, Spain; School of Pharmacy; University of East Anglia; Norwich Research Park; Norwich, UK. ^[4] Swedish NMR Centre; University of Gothenburg; Gothenburg, Sweden. ^[5]

关键词 DNA/RNA binding protein (D/RBP)RNA recognition motifs (RRM)TIA-1 saturation transfer difference-NMR (STD-NMR)scaffold independent analysis (SIA)surface plasmon resonance (SPR)