Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive.

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作者： Sébastien,Laurent ^[1] ; Adrien,Richard ^[2] ; Odile,Mulner-Lorillon ^[3] ; Julia,Morales ^[3] ; Didier,Flament ^[1] ; Virginie,Glippa ^[3] ; Jérémie,Bourdon ^[4] ; Pauline,Gosselin ^[3] ; Anne,Siegel ^[5] ; Patrick,Cormier ^[3] ; Robert,Bellé ^[3]

作者单位： Ifremer, UMR6197, Laboratoire de Microbiologie des Environnements Extrêmes Plouzané, France. ^[1] Université de Nice-Sophia Antipolis, UMR 7271, Laboratoire I3S Sophia, Antipolis, France. ^[2] Sorbonne Universités, UPMC University Paris 06, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development Station Biologique de Roscoff, Roscoff cedex, France ; CNRS, UMR 8227, Integrative Biology of Marine Models, Translation Cell Cycle and Development Station Biologique de Roscoff, Roscoff cedex, France. ^[3] CNRS UMR 6241, Laboratoire LINA, Université de Nantes Nantes, France. ^[4] CNRS, IRISA-UMR 6074, Campus de Beaulieu Rennes, France ; INRIA, Centre Rennes - Bretagne Atlantique, Symbiose, Campus de Beaulieu Rennes, France. ^[5]

关键词 deterministic model mechanisms of fertilization sea urchin embryos translation simulation translational control

DOI 10.3389/fgene.2014.00117

PMID 24834072

发布时间 2021-10-21

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Frontiers in genetics

2014年5卷

117页

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Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive.

Frontiers in genetics

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Modelization of the regulation of protein synthesis following fertilization in sea urchin shows requirement of two processes: a destabilization of eIF4E:4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both rapamycin-sensitive.

Frontiers in genetics

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Frontiers in genetics

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