Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.
作者:
主题词
成年人(Adult);算法(Algorithms);等位基因(Alleles);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);结肠肿瘤(Colonic Neoplasms);地诺前列酮(Dinoprostone);抗药性(Drug Resistance);女(雌)性(Female);疾病遗传易感性(Genetic Predisposition to Disease);遗传变异(Genetic Variation);杂合子(Heterozygote);人类(Humans);男(雄)性(Male);中年人(Middle Aged);突变(Mutation);有机阴离子转运子(Organic Anion Transporters);骨关节病, 原发肥大性(Osteoarthropathy, Primary Hypertrophic);系谱(Pedigree);表型(Phenotype);前列腺素(Prostaglandins);序列分析, DNA(Sequence Analysis, DNA)
DOI
10.1158/1940-6207.CAPR-14-0108
PMID
24838973
发布时间
2022-04-10
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