Molecular cloning and functional characterization of components of the capsule biosynthesis complex of Neisseria meningitidis serogroup A: toward in vitro vaccine production.

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第一作者： Timm,Fiebig

第一单位： From the Institute for Cellular Chemistry, Hannover Medical School, 30625 Hannover, Germany.

作者： Timm,Fiebig ^[1] ; Friedrich,Freiberger ^[1] ; Vittoria,Pinto ^[2] ; Maria Rosaria,Romano ^[2] ; Alan,Black ^[3] ; Christa,Litschko ^[1] ; Andrea,Bethe ^[1] ; Dmitry,Yashunsky ^[4] ; Roberto,Adamo ^[2] ; Andrei,Nikolaev ^[3] ; Francesco,Berti ^[5] ; Rita,Gerardy-Schahn ^[6]

作者单位： From the Institute for Cellular Chemistry, Hannover Medical School, 30625 Hannover, Germany. ^[1] Novartis Vaccines, Research, Via Fiorentina 1, 53100 Siena, Italy. ^[2] College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom, and. ^[3] the Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya Street 10, Moscow 119832, Russian Federation. ^[4] Novartis Vaccines, Research, Via Fiorentina 1, 53100 Siena, Italy, francesco.berti@novartis.com. ^[5] From the Institute for Cellular Chemistry, Hannover Medical School, 30625 Hannover, Germany, gerardy-schahn.rita@mh-hannover.de. ^[6]

关键词 Acetyltransferase Capsule Polymerase Enzyme Catalysis Epimerase Gram-negative Bacteria Neisseria meningitidis Serogroup A Nuclear Magnetic Resonance (NMR)Polysaccharide Recombinant Protein Expression Vaccine Development

主题词细菌荚膜(Bacterial Capsules);细菌蛋白质类(Bacterial Proteins);克隆, 分子(Cloning, Molecular);人类(Humans);脑膜炎双球菌菌苗(Meningococcal Vaccines);脑膜炎奈瑟球菌, 血清A群(Neisseria meningitidis, Serogroup A);多糖类, 细菌(Polysaccharides, Bacterial)

DOI 10.1074/jbc.M114.575142

PMID 24849599

发布时间 2021-10-21

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