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首页> Molecules (Basel, Switzerland)> Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives: finding new potential anticancer drugs.

Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives: finding new potential anticancer drugs.

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作者： Luana da S M,Forezi ^[1] ; Nathalia M C,Tolentino ^[1] ; Alessandra M T,de Souza ^[2] ; Helena C,Castro ^[3] ; Raquel C,Montenegro ^[4] ; Rafael F,Dantas ^[5] ; Maria E I M,Oliveira ^[5] ; Floriano P,Silva ^[5] ; Leilane H,Barreto ^[4] ; Rommel M R,Burbano ^[4] ; Bárbara,Abrahim-Vieira ^[2] ; Riethe,de Oliveira ^[2] ; Vitor F,Ferreira ^[1] ; Anna C,Cunha ^[1] ; Fernanda da C S,Boechat ^[1] ; Maria Cecília B V,de Souza ^[6]

作者单位： Outeiro de São João Batista, Fluminense FederalUniversity (UFF), s/n, Niterói 24020141, RJ, Brazil. ^[1] Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21949-900, RJ, Brazil. ^[2] LABIEMol, Outeiro de São João Batista, Fluminense Federal University, s/n, Niterói 24020-141, RJ, Brazil. ^[3] Institute of Biological Sciences, Federal University of Pará, Av. Augusto Corrêa, n.01-Guamá, Belém, 66075-110, Pará, Brazil. ^[4] Laboratory of Biochemistry of Proteins and Peptides, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, RJ, Brazil. ^[5] Outeiro de São João Batista, Fluminense FederalUniversity (UFF), s/n, Niterói 24020141, RJ, Brazil. gqocica@vm.uff.br. ^[6]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);细胞膜(Cell Membrane);计算机模拟(Computer Simulation);多柔比星(Doxorubicin);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);红细胞(Erythrocytes);溶血剂(Hemolytic Agents);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);小鼠(Mice);分子结构(Molecular Structure);喹诺酮类(Quinolones);胃肿瘤(Stomach Neoplasms)

DOI 10.3390/molecules19056651

PMID 24858098

发布时间 2021-10-21

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Molecules (Basel, Switzerland)

Molecules (Basel, Switzerland)

2014年19卷5期

6651-70页

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