首页> Journal of medicinal chemistry> Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.

Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.

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第一作者： R Ian,Storer

第一单位： Discovery Chemistry, ‡Discovery Biology, and §Pharmacokinetics, Dynamics and Metabolism, Sandwich Laboratories, Pfizer Global Research and Development , Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom.

作者： R Ian,Storer ^[1] ; Paul E,Brennan ; Alan D,Brown ; Peter J,Bungay ; Kelly M,Conlon ; Matthew S,Corbett ; Robert P,DePianta ; Paul V,Fish ; Alexander,Heifetz ; Danny K H,Ho ; Alan S,Jessiman ; Gordon,McMurray ; Cesar Augusto F,de Oliveira ; Lee R,Roberts ; James A,Root ; Veerabahu,Shanmugasundaram ; Michael J,Shapiro ; Melanie,Skerten ; Dominique,Westbrook ; Simon,Wheeler ; Gavin A,Whitlock ; John,Wright

作者单位： Discovery Chemistry, ‡Discovery Biology, and §Pharmacokinetics, Dynamics and Metabolism, Sandwich Laboratories, Pfizer Global Research and Development , Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom. ^[1]