The [18F]FDG μPET readout of a brain activation model to evaluate the metabotropic glutamate receptor 2 positive allosteric modulator JNJ-42153605.
第一作者:
Tine,Wyckhuys
第一单位:
Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium (T.W., St.S.); Nuclear Medicine Department, University Hospital, Antwerp, Belgium (L.w., Si.S.); and Department of Neuroscience, Janssen Pharmaceutica NV, Beerse, Belgium (X.L., M.S.).
作者:
医学主题词
别构调节(Allosteric Regulation);动物(Animals);脑(Brain);环硫氧化物(Cyclic S-Oxides);剂量效应关系, 药物(Dose-Response Relationship, Drug);氟脱氧葡萄糖F18(Fluorodeoxyglucose F18);氯胺酮(Ketamine);男(雄)性(Male);美金刚(Memantine);吡啶类(Pyridines);放射性药物(Radiopharmaceuticals);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 亲代谢性谷氨酸盐(Receptors, Metabotropic Glutamate);三嗪类(Triazines)
DOI
10.1124/jpet.114.213959
PMID
24898267
发布时间
2025-03-06
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