Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes.

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作者： Yimin,Qian ^[1] ; Wendy L,Corbett ^[1] ; Steven J,Berthel ^[1] ; Duk Soon,Choi ^[1] ; Mark T,Dvorozniak ^[1] ; Wanping,Geng ^[1] ; Paul,Gillespie ^[1] ; Kevin R,Guertin ^[1] ; Nancy-Ellen,Haynes ^[1] ; Robert F,Kester ^[1] ; Francis A,Mennona ^[1] ; David,Moore ^[1] ; Jagdish,Racha ^[1] ; Roumen,Radinov ^[1] ; Ramakanth,Sarabu ^[1] ; Nathan R,Scott ^[1] ; Joseph,Grimsby ^[1] ; Navita L,Mallalieu ^[1]

作者单位： Departments of Discovery Chemistry, Pharmaceutical and Analytical Research, Metabolic and Vascular Diseases, Drug Metabolism and Pharmacokinetics, Process Research, Clinical Pharmacology, Hoffmann-La Roche , 340 Kingsland Street, Nutley, New Jersey 07110, United States. ^[1]

关键词 Glucokinase activator lipophilic ligand efficiency metabolite redox cycling type 2 diabetes

DOI 10.1021/ml400027y

PMID 24900686

发布时间 2021-10-21

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