Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice.-论文-万方医学网

第一作者： P,Macor

第一单位： Department of Life Sciences, University of Trieste, Trieste, Italy.

作者： P,Macor ^[1] ; E,Secco ^[1] ; N,Mezzaroba ^[1] ; S,Zorzet ^[1] ; P,Durigutto ^[1] ; T,Gaiotto ^[2] ; L,De Maso ^[1] ; S,Biffi ^[3] ; C,Garrovo ^[3] ; S,Capolla ^[1] ; C,Tripodo ^[4] ; V,Gattei ^[5] ; R,Marzari ^[1] ; F,Tedesco ^[6] ; D,Sblattero ^[7]

作者单位： Department of Life Sciences, University of Trieste, Trieste, Italy. ^[1] National Institute for Biological Standards and Control (NIBSC), Hertfordshire, UK. ^[2] Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy. ^[3] Department of Human Pathology, University of Palermo, Palermo, Italy. ^[4] Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano, Italy. ^[5] IRCCS Istituto Auxologico Italiano, Milan, Italy. ^[6] Department of Health Sciences and IRCAD, University of Eastern Piedmont, Novara, Italy. ^[7]

主题词动物(Animals);抗体(Antibodies);抗体, 双特异性(Antibodies, Bispecific);抗体依赖细胞细胞毒性(Antibody-Dependent Cell Cytotoxicity);抗原, CD20(Antigens, CD20);伯基特淋巴瘤(Burkitt Lymphoma);细胞分离(Cell Separation);克隆, 分子(Cloning, Molecular);补体系统蛋白质类(Complement System Proteins);疾病模型, 动物(Disease Models, Animal);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);女(雌)性(Female);流式细胞术(Flow Cytometry);人类(Humans);免疫疗法(Immunotherapy);杀伤细胞, 天然(Killer Cells, Natural);巨噬细胞(Macrophages);小鼠(Mice);小鼠, SCID(Mice, SCID);显微镜检查, 荧光(Microscopy, Fluorescence)

DOI 10.1038/leu.2014.185

PMID 24903480

发布时间 2021-10-21

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Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice.

Leukemia

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Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice.

Leukemia

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Leukemia

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检索历史清除