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Synthesis and SAR studies of benzyl ether derivatives as potent orally active S1P₁ agonists.

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第一作者： Takashi,Tsuji

第一单位： Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.

作者： Takashi,Tsuji ^[1] ; Keisuke,Suzuki ^[1] ; Tsuyoshi,Nakamura ^[1] ; Taiji,Goto ^[1] ; Yukiko,Sekiguchi ^[2] ; Takuya,Ikeda ^[1] ; Takeshi,Fukuda ^[1] ; Toshiyasu,Takemoto ^[1] ; Yumiko,Mizuno ^[3] ; Takako,Kimura ^[1] ; Yumi,Kawase ^[4] ; Futoshi,Nara ^[4] ; Takashi,Kagari ^[5] ; Takaichi,Shimozato ^[5] ; Chizuko,Yahara ^[6] ; Shinichi,Inaba ^[6] ; Tomohiro,Honda ^[6] ; Takashi,Izumi ^[6] ; Masakazu,Tamura ^[7] ; Takahide,Nishi ^[8]

作者单位： Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[1] New Modality Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[2] New Drug Regulatory Affairs Department, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[3] Cardiovascular-Metabolics Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[4] Frontier Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[5] Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[6] Biologics Pharmacology Research Laboratories, Daiichi Sankyo Co, Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. ^[7] Daiichi Sankyo India Pharma Pvt. Ltd, Village Sarhaul, Sector 18, Udyog Vihar Industrial Area, Gurgaon 122015, Haryana, India. Electronic address: takahide.nishi.wd@dsin.co.in. ^[8]

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