Anticancer ruthenium(III) complex KP1019 interferes with ATP-dependent Ca2+ translocation by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

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作者： Fabrizio-Zagros,Sadafi ^[1] ; Lara,Massai ; Gianluca,Bartolommei ; Maria Rosa,Moncelli ; Luigi,Messori ; Francesco,Tadini-Buoninsegni

作者单位： Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (Italy); Institute of Particle Technology, University of Erlangen-Nuremberg, 91058 Erlangen (Germany). ^[1]

关键词 ATPase inhibitors SERCA anticancer drugs metallodrugs sarco-endoplasmic reticulum Ca2+-ATPase solid-supported membrane

主题词腺苷三磷酸(Adenosine Triphosphate);抗肿瘤药(Antineoplastic Agents);钙(Calcium);顺铂(Cisplatin);配位络合物(Coordination Complexes);二甲亚砜(Dimethyl Sulfoxide);吲唑类(Indazoles);有机金属化合物(Organometallic Compounds);蛋白质结合(Protein Binding);钌化合物(Ruthenium Compounds);肌浆网钙转运ATP酶类(Sarcoplasmic Reticulum Calcium-Transporting ATPases)

DOI 10.1002/cmdc.201402128

PMID 24920093

发布时间 2019-12-10

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ChemMedChem

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Anticancer ruthenium(III) complex KP1019 interferes with ATP-dependent Ca2+ translocation by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

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Anticancer ruthenium(III) complex KP1019 interferes with ATP-dependent Ca2+ translocation by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA).

ChemMedChem

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ChemMedChem

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