Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by upregulating SHP2 activation to overcome contact dermatitis.

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作者： Xingqi,Wang ^[1] ; Aihua,Zhang ^[1] ; Jian,Gao ^[1] ; Wei,Chen ^[1] ; Shiyu,Wang ^[1] ; Xuefeng,Wu ^[1] ; Yan,Shen ^[1] ; Yuehai,Ke ^[2] ; Zichun,Hua ^[1] ; Renxiang,Tan ^[3] ; Yang,Sun ^[4] ; Qiang,Xu ^[5]

作者单位： State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. ^[1] Laboratory of Cell Signaling and Modeling Genetics, Institute of Molecular Pathology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, China. ^[2] State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. Electronic address: rxtan@nju.edu.cn. ^[3] State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. Electronic address: yangsun@nju.edu.cn. ^[4] State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China. Electronic address: molpharm@163.com. ^[5]