MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.

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第一作者： Jixin,Zhong

第一单位： The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China.

作者： Jixin,Zhong ^[1] ; Qilin,Yu ^[1] ; Ping,Yang ^[1] ; Xiaoquan,Rao ^[2] ; Long,He ^[1] ; Jing,Fang ^[1] ; Yaqin,Tu ^[1] ; Zhijun,Zhang ^[1] ; Qiaohong,Lai ^[1] ; Shu,Zhang ^[1] ; Michal,Kuczma ^[2] ; Piatr,Kraj ^[2] ; Jun-Fa,Xu ^[3] ; Feili,Gong ^[4] ; Jianfeng,Zhou ^[5] ; Li,Wen ^[6] ; Decio L,Eizirik ^[7] ; Jie,Du ^[8] ; Wei,Wang ^[9] ; Cong-Yi,Wang ^[10]

作者单位： The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China. ^[1] The Center for Biotechnology and Genomic Medicine, Georgia Regents University, 1120 15th Street, Augusta, GA 30912, USA. ^[2] Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China. ^[3] Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. ^[4] Department of Hematology, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China. ^[5] Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. ^[6] Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik 808, CP 618, B-1070 Brussels, Belgium. ^[7] Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing, China. ^[8] Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China. Electronic address: wwang@tjh.tjmu.edu.cn. ^[9] The Center for Biomedical Research, Tongji Hospital, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan 430030, China. Electronic address: wangcy@tjh.tjmu.edu.cn. ^[10]

关键词 EAE Epigenetic MBD2 Methylation T(H)17 T-bet

主题词动物(Animals);细胞分化(Cell Differentiation);DNA结合蛋白质类(DNA-Binding Proteins);脑脊髓炎, 自身免疫性, 实验性(Encephalomyelitis, Autoimmune, Experimental);后成说, 遗传(Epigenesis, Genetic);同源盒结构域蛋白质类(Homeodomain Proteins);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肽碎片(Peptide Fragments);T盒域蛋白质类(T-Box Domain Proteins);Th17细胞(Th17 Cells);转录因子(Transcription Factors)

DOI 10.1016/j.jaut.2014.05.006

PMID 24934598

发布时间 2014-09-11

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Journal of autoimmunity

2014年53卷

95-104页

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MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.

Journal of autoimmunity

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Journal of autoimmunity

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MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.

Journal of autoimmunity

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Journal of autoimmunity

相关期刊

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