换一批
换一批Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling.
作者：
主题词
投药, 口服(Administration, Oral);青少年(Adolescent);成年人(Adult);老年人(Aged);动物替代试验(Animal Testing Alternatives);动物(Animals);生物转化(Biotransformation);Caco-2细胞(Caco-2 Cells);细胞分化(Cell Differentiation);计算机模拟(Computer Simulation);剂量效应关系, 药物(Dose-Response Relationship, Drug);胚胎干细胞(Embryonic Stem Cells);可行性研究(Feasibility Studies);女(雌)性(Female);人类(Humans);肠吸收(Intestinal Absorption);动力学(Kinetics);男(雄)性(Male);代谢清除率(Metabolic Clearance Rate);中年人(Middle Aged);模型, 生物学(Models, Biological);大鼠(Rats);结果可重复性(Reproducibility of Results);危险性评估(Risk Assessment);毒性试验(Toxicity Tests);维甲酸(Tretinoin);青年人(Young Adult)
DOI
10.1007/s00204-014-1289-4
PMID
24935252
发布时间
2019-12-10
- 浏览17
Archives of toxicology
1135-48页
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