换一批Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer.
第一作者：
Vijayalakshmi,Shanmugam
第一单位：
Translational Genomics Research Institute (TGen), 445 N Fifth Street, Phoenix, AZ 85004, USA. jcarpten@tgen.org.
作者：
医学主题词
老年人(Aged);印迹法, 蛋白质(Blotting, Western);细胞增殖(Cell Proliferation);结直肠肿瘤(Colorectal Neoplasms);DNA拷贝数变异(DNA Copy Number Variations);基因沉默(Gene Silencing);疾病遗传易感性(Genetic Predisposition to Disease);基因组, 人(Genome, Human);HCT116细胞(HCT116 Cells);HEK293细胞(HEK293 Cells);人类(Humans);INDEL突变(INDEL Mutation);男(雄)性(Male);中年人(Middle Aged);分子靶向治疗(Molecular Targeted Therapy);突变(Mutation);肿瘤转移(Neoplasm Metastasis);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);磷酸单酯水解酶类(Phosphoric Monoester Hydrolases);多态性, 单核苷酸(Polymorphism, Single Nucleotide);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));RNA, 小分子干扰(RNA, Small Interfering);序列分析, DNA(Sequence Analysis, DNA);信号传导(Signal Transduction);ras蛋白质类(ras Proteins)
DOI
10.1186/1755-8794-7-36
PMID
24943349
发布时间
2021-10-21
- 浏览13
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
