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Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα.

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第一作者： Keisuke,Yamamoto

第一单位： Department of Gastroenterology, Department of Hematology and Oncology and Department of Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan, Division of Clinical Genome Research, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan, Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo, 113-8655, Japan and Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi-cho, Kofu-shi, Yamanashi-Prefecture 400-8506, Japan.

作者： Keisuke,Yamamoto ^[1] ; Keisuke,Tateishi ^[2] ; Yotaro,Kudo ^[1] ; Tomohiko,Sato ^[3] ; Shinzo,Yamamoto ^[1] ; Koji,Miyabayashi ^[1] ; Keisuke,Matsusaka ^[4] ; Yoshinari,Asaoka ^[1] ; Hideaki,Ijichi ^[1] ; Yoshihiro,Hirata ^[1] ; Motoyuki,Otsuka ^[1] ; Yousuke,Nakai ^[1] ; Hiroyuki,Isayama ^[1] ; Tsuneo,Ikenoue ^[5] ; Mineo,Kurokawa ^[3] ; Masashi,Fukayama ^[4] ; Norihiro,Kokudo ^[6] ; Masao,Omata ^[7] ; Kazuhiko,Koike ^[1]

作者单位： Department of Gastroenterology, Department of Hematology and Oncology and Department of Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan, Division of Clinical Genome Research, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan, Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo, 113-8655, Japan and Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi-cho, Kofu-shi, Yamanashi-Prefecture 400-8506, Japan. ^[1] Department of Gastroenterology, Department of Hematology and Oncology and Department of Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan, Division of Clinical Genome Research, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan, Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo, 113-8655, Japan and Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi-cho, Kofu-shi, Yamanashi-Prefecture 400-8506, Japan ktate-tky@umin.ac.jp. ^[2] Department of Hematology and Oncology and. ^[3] Department of Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ^[4] Division of Clinical Genome Research, The Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. ^[5] Hepato-Biliary-Pancreatic Surgery Division, Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo , Bunkyo-ku, Tokyo, 113-8655, Japan and. ^[6] Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi-cho, Kofu-shi, Yamanashi-Prefecture 400-8506, Japan. ^[7]