Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.
第一作者:
Dong-Hoon,Chung
第一单位:
Departments of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, United States of America; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, United States of America.
作者:
主题词
动物(Animals);抗病毒药(Antiviral Agents);细胞系(Cell Line);仓鼠亚科(Cricetinae);疾病模型, 动物(Disease Models, Animal);抗药性, 病毒(Drug Resistance, Viral);脑炎病毒, 委内瑞拉马(Encephalitis Virus, Venezuelan Equine);脑脊髓炎, 委内瑞拉马(Encephalomyelitis, Venezuelan Equine);高通量筛选分析(High-Throughput Screening Assays);小鼠(Mice);小鼠, 近交C3H(Mice, Inbred C3H);喹唑啉酮类(Quinazolinones);种特异性(Species Specificity);构效关系(Structure-Activity Relationship);Vero细胞(Vero Cells);病毒复制(Virus Replication)
DOI
10.1371/journal.ppat.1004213
PMID
24967809
发布时间
2021-10-21
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PLoS pathogens
e1004213页
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