Synthesis and biological evaluation of α-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class of α-glucosidase inhibitors.

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第一作者： Yoshihiro,Natori

第一单位： Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.

作者： Yoshihiro,Natori ^[1] ; Toshihiro,Sakuma ^[1] ; Yuichi,Yoshimura ^[2] ; Kyoko,Kinami ^[3] ; Yuki,Hirokami ^[3] ; Kasumi,Sato ^[3] ; Isao,Adachi ^[3] ; Atsushi,Kato ^[4] ; Hiroki,Takahata ^[1]

作者单位： Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan. ^[1] Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan. Electronic address: yoshimura@tohoku-pharm.ac.jp. ^[2] Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan. ^[3] Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan. Electronic address: kato@med.u-toyama.ac.jp. ^[4]

关键词 1-C-4′-Arylbutyl-l-arabinoiminofuranoses Iminosugars Structure–activity relationship Type-2 diabetes α-Glucosidase inhibitor

主题词剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);亚氨基糖类(Imino Sugars);肠(Intestines);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship);α葡糖苷酶类(alpha-Glucosidases)

DOI 10.1016/j.bmcl.2014.06.001

PMID 24973028

发布时间 2014-07-11

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