Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions.
作者:
主题词
腺癌(Adenocarcinoma);动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);苯甲酰胺类(Benzamides);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);环氧化酶2(Cyclooxygenase 2);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);女(雌)性(Female);肺肿瘤(Lung Neoplasms);淋巴管生成(Lymphangiogenesis);淋巴转移(Lymphatic Metastasis);巨噬细胞(Macrophages);乳房肿瘤, 实验性(Mammary Neoplasms, Experimental);小鼠(Mice);小鼠, 近交C3H(Mice, Inbred C3H);分子靶向治疗(Molecular Targeted Therapy);肿瘤移植(Neoplasm Transplantation);肿瘤干细胞(Neoplastic Stem Cells);新生血管化, 病理性(Neovascularization, Pathologic);吡唑类(Pyrazoles);受体, 前列腺素E, EP4亚型(Receptors, Prostaglandin E, EP4 Subtype);磺胺类(Sulfonamides);肿瘤负荷(Tumor Burden);血管内皮生长因子A(Vascular Endothelial Growth Factor A)
DOI
10.1111/cas.12475
PMID
24981602
发布时间
2024-03-23
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Cancer science
1142-51页
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