Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.

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第一作者： Marina N,Semenova

第一单位： Institute of Developmental Biology, RAS, Vavilov Street, 26, 119334 Moscow, Russia; Chemical Block Ltd, 3 Kyriacou Matsi, 3723 Limassol, Cyprus. Electronic address: ms@chemical-block.com.

作者： Marina N,Semenova ^[1] ; Dmitry V,Tsyganov ^[2] ; Oleg R,Malyshev ^[3] ; Oleg V,Ershov ^[4] ; Ivan N,Bardasov ^[5] ; Roman V,Semenov ^[6] ; Alex S,Kiselyov ^[7] ; Victor V,Semenov ^[8]

作者单位： Institute of Developmental Biology, RAS, Vavilov Street, 26, 119334 Moscow, Russia; Chemical Block Ltd, 3 Kyriacou Matsi, 3723 Limassol, Cyprus. Electronic address: ms@chemical-block.com. ^[1] N. D. Zelinsky Institute of Organic Chemistry, RAS, Leninsky Prospect, 47, 119991 Moscow, Russia. Electronic address: tsyg@ioc.ac.ru. ^[2] N. D. Zelinsky Institute of Organic Chemistry, RAS, Leninsky Prospect, 47, 119991 Moscow, Russia. Electronic address: olegmalyshev1969@gmail.com. ^[3] I. N. Ulyanov Chuvash State University, Moskovskiy pr., 15, 428015 Cheboksary, Russia. Electronic address: oleg.ershov@mail.ru. ^[4] I. N. Ulyanov Chuvash State University, Moskovskiy pr., 15, 428015 Cheboksary, Russia. Electronic address: bardasov.chem@mail.ru. ^[5] N. D. Zelinsky Institute of Organic Chemistry, RAS, Leninsky Prospect, 47, 119991 Moscow, Russia. Electronic address: rs@chemical-block.com. ^[6] Department of Biological and Medicinal Chemistry, Moscow Institute of Physics and Technology, Institutsky Per. 9, Dolgoprudny, Moscow Region 141700, Russia. Electronic address: ask@chemdiv.com. ^[7] Chemical Block Ltd, 3 Kyriacou Matsi, 3723 Limassol, Cyprus; N. D. Zelinsky Institute of Organic Chemistry, RAS, Leninsky Prospect, 47, 119991 Moscow, Russia. Electronic address: vs@zelinsky.ru. ^[8]

关键词 4H-Chromenes Cytotoxicity Microtubule destabilizing agents Oxa-podophyllotoxins Sea urchin embryo