首页> Bioorganic & medicinal chemistry letters> Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.

Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.

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第一作者： Junichiro,Yamamoto

第一单位： Fuji Research Park, Research Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Suntou-gun, Shizuoka 411-8731, Japan. Electronic address: junichiro.yamamoto@kyowa-kirin.co.jp.

作者： Junichiro,Yamamoto ^[1] ; Nobuyoshi,Amishiro ^[2] ; Kazuhiko,Kato ^[2] ; Yoshihisa,Ohta ^[2] ; Yoji,Ino ^[2] ; Mitsuharu,Araki ^[2] ; Tetsuya,Tsujita ^[2] ; Seiho,Okamoto ^[2] ; Takeshi,Takahashi ^[2] ; Hideaki,Kusaka ^[2] ; Shiro,Akinaga ^[2] ; Yoshinori,Yamashita ^[2] ; Ryuichiro,Nakai ^[2] ; Chikara,Murakata ^[2]

作者单位： Fuji Research Park, Research Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Suntou-gun, Shizuoka 411-8731, Japan. Electronic address: junichiro.yamamoto@kyowa-kirin.co.jp. ^[1] Fuji Research Park, Research Division, Kyowa Hakko Kirin Co., Ltd, 1188 Shimotogari, Nagaizumi-cho, Suntou-gun, Shizuoka 411-8731, Japan. ^[2]

关键词 Mitotic kinesin Eg5 inhibitor Thiadiazoline derivatives

医学主题词剂量效应关系, 药物(Dose-Response Relationship, Drug);酶抑制剂(Enzyme Inhibitors);人类(Humans);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship);噻唑烷类(Thiazolidines)

DOI 10.1016/j.bmcl.2014.06.034

PMID 25001485

发布时间 2021-12-03

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准确一般字义偏差语意偏离译文作用小提交