换一批
换一批The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases.
第一单位：
Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado Postal 70-248, México DF 04510, México.
作者：
关键词
Batimastat (BB-94) (CID 5362422). Galardin (GM 6001) (PubChem CID 132519)GSK2334470, (3S,6R)-1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide. ) (PubChem CID 46215815)OSU-03012, (2-amino-N-[4-[5-(2-phenanthrenyl)-3-trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide) (PubChem CID 10027278)PDK1Protein fragmentationProtein kinaseProtein kinase inhibitorStaurosporine (PubChem CID 44259)UCN-01UCN-01, (7-hydroxystaurosporine (3R*,8S*, 9R*, 10R*,12R*)-2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-8,12-epoxy-1H, 8H-2,7b,12a-triazadibenzo[a,g]-cyclonona[cde]triden-1-one) (PubChem CID 3078519)
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞系, 肿瘤(Cell Line, Tumor);仓鼠亚科(Cricetinae);吲唑类(Indazoles);金属蛋白酶类(Metalloproteases);蛋白激酶抑制剂(Protein Kinase Inhibitors);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);星状孢子素(Staurosporine);磺胺类(Sulfonamides)
DOI
10.1016/j.ejphar.2014.06.057
PMID
25016091
发布时间
2021-12-03
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