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Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333.

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第一作者： Corinne,Beinat

第一单位： School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

作者： Corinne,Beinat ^[1] ; Tristan,Reekie ^[1] ; David,Hibbs ^[2] ; Teresa,Xie ^[3] ; Thao T,Olson ^[3] ; Yingxian,Xiao ^[3] ; Andrew,Harvey ^[4] ; Susan,O'Connor ^[4] ; Carolyn,Coles ^[4] ; John,Tsanaktsidis ^[5] ; Michael,Kassiou ^[6]

作者单位： School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. ^[1] School of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia. ^[2] Department of Pharmacology and Physiology, Georgetown University, Washington, DC 20057, USA. ^[3] Bionomics Limited, Thebarton, SA 5031, Australia. ^[4] CSIRO Materials Science & Engineering, Ian Wark Laboratory, Bayview Avenue, Clayton Victoria 3168, Australia. ^[5] School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia; Discipline of Medical Radiation Sciences, The University of Sydney, Sydney, NSW 2006, Australia; Brain and Mind Research Institute, Sydney, NSW 2050, Australia. Electronic address: michael.kassiou@sydney.edu.au. ^[6]

关键词 AChR Acetylcholine receptor CNS Isostere Structure–activity relationships Tetrazole α(7) nicotinic receptors