HMGB1 promotes the development of pulmonary arterial hypertension in rats.-论文-万方医学网

作者： Yukari,Sadamura-Takenaka ^[1] ; Takashi,Ito ^[2] ; Satoshi,Noma ^[1] ; Yoko,Oyama ^[3] ; Shingo,Yamada ^[4] ; Ko-ichi,Kawahara ^[5] ; Hiromasa,Inoue ^[6] ; Ikuro,Maruyama ^[2]

作者单位： Department of Pulmonary Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. ^[1] Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. ^[2] Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. ^[3] Shino-Test Corporation, Sagamihara, Japan. ^[4] Department of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan. ^[5] Department of Pulmonary Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. ^[6]

主题词动物(Animals);支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid);趋化因子CCL2(Chemokine CCL2);DNA结合蛋白质类(DNA-Binding Proteins);疾病模型, 动物(Disease Models, Animal);内皮缩血管肽1(Endothelin-1);HMGB1蛋白质(HMGB1 Protein);血流动力学(Hemodynamics);高血压, 肺性(Hypertension, Pulmonary);肥大, 右心室(Hypertrophy, Right Ventricular);炎症(Inflammation);白细胞介素1β(Interleukin-1beta);男(雄)性(Male);野百合碱(Monocrotaline);肺动脉(Pulmonary Artery);随机分配(Random Allocation);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);血管阻力(Vascular Resistance);心室功能障碍, 右(Ventricular Dysfunction, Right)

DOI 10.1371/journal.pone.0102482

PMID 25032709

发布时间 2021-10-21

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HMGB1 promotes the development of pulmonary arterial hypertension in rats.

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HMGB1 promotes the development of pulmonary arterial hypertension in rats.

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