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Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death.

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第一作者： Michail,Nomikos

第一单位： Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Cardiff CF14 4XN, UK. Electronic address: mixosn@yahoo.com.

作者： Michail,Nomikos ^[1] ; Angelos,Thanassoulas ^[2] ; Konrad,Beck ^[3] ; Vyronia,Vassilakopoulou ^[4] ; Handan,Hu ^[5] ; Brian L,Calver ^[5] ; Maria,Theodoridou ^[4] ; Junaid,Kashir ^[5] ; Lynda,Blayney ^[5] ; Evangelia,Livaniou ^[2] ; Pierre,Rizkallah ^[5] ; George,Nounesis ^[2] ; F Anthony,Lai ^[5]

作者单位： Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Cardiff CF14 4XN, UK. Electronic address: mixosn@yahoo.com. ^[1] National Center for Scientific Research "Demokritos", 15310 Aghia Paraskevi, Greece. ^[2] School of Dentistry, Cardiff University, Cardiff CF14 4XY, UK. ^[3] Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Cardiff CF14 4XN, UK; National Center for Scientific Research "Demokritos", 15310 Aghia Paraskevi, Greece. ^[4] Wales Heart Research Institute, Cardiff University School of Medicine, Institute of Molecular and Experimental Medicine, Cardiff CF14 4XN, UK. ^[5]

关键词 Calcium Calmodulin Idiopathic ventricular fibrillation RyR2 calcium release channel Ryanodine receptor Sudden cardiac death