Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology.

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作者： Cristiana,Branco da Cunha ^[1] ; Darinka D,Klumpers ^[2] ; Weiwei A,Li ^[3] ; Sandeep T,Koshy ^[4] ; James C,Weaver ^[5] ; Ovijit,Chaudhuri ^[6] ; Pedro L,Granja ^[7] ; David J,Mooney ^[8]

作者单位： School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), 4200-465 Porto, Portugal; Instituto de Engenharia Biomédica da Universidade do Porto (INEB), 4150-180 Porto, Portugal; Faculdade de Medicina da Universidade do Porto (FMUP)/Hospital S. João, 4200-319 Porto, Portugal. ^[1] School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Dept. Orthopedic Surgery, Research Institute MOVE, VU University Medical Center, 1081 HV, Amsterdam, The Netherlands. ^[2] School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. ^[3] School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 10239, USA. ^[4] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. ^[5] Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA. ^[6] Instituto de Engenharia Biomédica da Universidade do Porto (INEB), 4150-180 Porto, Portugal; Departamento de Engenharia Metalúrgica e Materiais, Faculdade de Engenharia da Universidade do Porto (FEUP), 4200-465 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS), 4050-313 Porto, Portugal. ^[7] School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: mooneyd@seas.harvard.edu. ^[8]

关键词 ECM (extracellular matrix)Inflammation Interpenetrating networks (IPNs)Mechanical properties Wound dressing biomaterial Wound healing