β-cell induction in vivo in severely diabetic male mice by changing the circulating levels and pattern of the ratios of estradiol to androgens.
第一作者:
Akari,Inada
第一单位:
Departments of Diabetes and Genes and Advanced Medical Initiatives (A.I., O.I., K.F.), Developmental Molecular Anatomy (T.I.), and Pathophysiological and Experimental Pathology (HY.F., K.S.), and Medical Institute of Bioregulation (K.K.), Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; and Department of Health Promotion Sciences (N.L.F.), Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan.
作者:
主题词
雄激素类(Androgens);动物(Animals);血糖(Blood Glucose);细胞增殖(Cell Proliferation);cAMP应答元件调节器(Cyclic AMP Response Element Modulator);糖尿病, 实验性(Diabetes Mellitus, Experimental);雌二醇(Estradiol);女(雌)性(Female);胰岛素分泌细胞(Insulin-Secreting Cells);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 转基因(Mice, Transgenic);睾丸切除术(Orchiectomy);疾病严重程度指数(Severity of Illness Index)
DOI
10.1210/en.2014-1254
PMID
25057794
发布时间
2014-09-20
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Endocrinology
3829-42页
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