Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.-论文-万方医学网

第一作者： Jian,Xu

第一单位： Child Study Center, Yale University, New Haven, Connecticut, United States of America.

作者： Jian,Xu ^[1] ; Manavi,Chatterjee ^[1] ; Tyler D,Baguley ^[2] ; Jonathan,Brouillette ^[1] ; Pradeep,Kurup ^[1] ; Debolina,Ghosh ^[1] ; Jean,Kanyo ^[3] ; Yang,Zhang ^[4] ; Kathleen,Seyb ^[5] ; Chimezie,Ononenyi ^[1] ; Ethan,Foscue ^[1] ; George M,Anderson ^[6] ; Jodi,Gresack ^[7] ; Gregory D,Cuny ^[5] ; Marcie A,Glicksman ^[5] ; Paul,Greengard ^[7] ; TuKiet T,Lam ^[3] ; Lutz,Tautz ^[8] ; Angus C,Nairn ^[9] ; Jonathan A,Ellman ^[2] ; Paul J,Lombroso ^[10]

作者单位： Child Study Center, Yale University, New Haven, Connecticut, United States of America. ^[1] Department of Chemistry, Yale University, New Haven, Connecticut, United States of America. ^[2] Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America. ^[3] Child Study Center, Yale University, New Haven, Connecticut, United States of America; Laboratory for Drug Discovery in Neurodegeneration and Department of Neurology, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America. ^[4] Laboratory for Drug Discovery in Neurodegeneration and Department of Neurology, Brigham and Women's Hospital, Cambridge, Massachusetts, United States of America. ^[5] Child Study Center, Yale University, New Haven, Connecticut, United States of America; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, United States of America. ^[6] Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, United States of America. ^[7] Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America. ^[8] Department of Psychiatry, Yale University, New Haven, Connecticut, United States of America. ^[9] Child Study Center, Yale University, New Haven, Connecticut, United States of America; Department of Psychiatry, Yale University, New Haven, Connecticut, United States of America; Department of Neurobiology, Yale University, New Haven, Connecticut, United States of America. ^[10]

主题词阿尔茨海默病(Alzheimer Disease);氨基酸序列(Amino Acid Sequence);动物(Animals);苯硫|艹卓|类(Benzothiepins);催化域(Catalytic Domain);细胞死亡(Cell Death);大脑皮质(Cerebral Cortex);认知障碍(Cognition Disorders);半胱氨酸(Cysteine);疾病模型, 动物(Disease Models, Animal);酶抑制剂(Enzyme Inhibitors);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);分子序列数据(Molecular Sequence Data);神经元(Neurons);磷酰化(Phosphorylation);磷酸酪氨酸(Phosphotyrosine);蛋白质酪氨酸磷酸酶类, 非受体(Protein Tyrosine Phosphatases, Non-Receptor);底物特异性(Substrate Specificity)

DOI 10.1371/journal.pbio.1001923

PMID 25093460

发布时间 2022-03-30

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Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

PLoS biology

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Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

PLoS biology

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PLoS biology

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