Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.

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第一作者： Henna,Martiskainen

第一单位： Institute of Clinical Medicine - Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland.

作者： Henna,Martiskainen ^[1] ; Seppo,Helisalmi ^[1] ; Jayashree,Viswanathan ^[1] ; Mitja,Kurki ^[2] ; Anette,Hall ^[1] ; Sanna-Kaisa,Herukka ^[1] ; Timo,Sarajärvi ^[1] ; Teemu,Natunen ^[1] ; Kaisa M A,Kurkinen ^[1] ; Jaakko,Huovinen ^[1] ; Petra,Mäkinen ^[1] ; Marjo,Laitinen ^[1] ; Anne M,Koivisto ^[1] ; Kari M,Mattila ^[3] ; Terho,Lehtimäki ^[3] ; Anne M,Remes ^[1] ; Ville,Leinonen ^[2] ; Annakaisa,Haapasalo ^[1] ; Hilkka,Soininen ^[1] ; Mikko,Hiltunen ^[4]

作者单位： Institute of Clinical Medicine - Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland. ^[1] Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland, Kuopio, Finland. ^[2] Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland. ^[3] Institute of Clinical Medicine - Neurology, University of Eastern Finland, and Department of Neurology, Kuopio University Hospital, Kuopio, Finland Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. ^[4]

关键词 Alzheimer's disease amyloid-β peptide biomarker cerebrospinal fluid polygenic risk score risk gene tau protein