TGFβ induces "BRCAness" and sensitivity to PARP inhibition in breast cancer by regulating DNA-repair genes.

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作者： Liang,Liu ^[1] ; Weiying,Zhou ^[2] ; Chun-Ting,Cheng ^[3] ; Xiubao,Ren ^[4] ; George,Somlo ^[5] ; Miranda Y,Fong ^[6] ; Andrew R,Chin ^[7] ; Hui,Li ^[4] ; Yang,Yu ^[4] ; Yang,Xu ^[6] ; Sean Timothy Francis,O'Connor ^[6] ; Timothy R,O'Connor ^[6] ; David K,Ann ^[8] ; Jeremy M,Stark ^[9] ; Shizhen Emily,Wang ^[10]

作者单位： Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. ^[1] Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing, China. ^[2] Department of Molecular Pharmacology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. City of Hope Irell and Manella Graduate School of Biological Sciences, Duarte, California. ^[3] Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. ^[4] Department of Medical Oncology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. ^[5] Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. ^[6] Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. City of Hope Irell and Manella Graduate School of Biological Sciences, Duarte, California. ^[7] Department of Molecular Pharmacology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. ^[8] Department of Radiation Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. ^[9] Department of Cancer Biology, City of Hope Beckman Research Institute and Medical Center, Duarte, California. Department of Biotherapy and Key Laboratory of Cancer Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. ewang@coh.org. ^[10]