Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates.

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作者： Boudewijn A,Duivenvoorden ^[1] ; Karen,Ghauharali ^[2] ; Saskia,Scheij ^[2] ; Rolf G,Boot ^[2] ; Johannes M F G,Aerts ^[2] ; Gijsbert A,van der Marel ^[1] ; Herman S,Overkleeft ^[3] ; Jeroen D C,Codée ^[4]

作者单位： Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2300 RA Leiden, The Netherlands. ^[1] Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. ^[2] Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address: h.s.overkleeft@chem.leidenuniv.nl. ^[3] Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, Einsteinweg 55, 2300 RA Leiden, The Netherlands. Electronic address: jcodee@chem.leidenuniv.nl. ^[4]

关键词 Chitotriosidase Diagnostic tools Fluorogenic substrates Glycosylation Marker enzyme

主题词二糖类(Disaccharides);药物设计(Drug Design);己糖胺酶类(Hexosaminidases);人类(Humans);羟甲香豆素(Hymecromone);分子结构(Molecular Structure);底物特异性(Substrate Specificity)

DOI 10.1016/j.carres.2014.07.007

PMID 25104395

发布时间 2014-11-05

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