Transforming growth factor-β-independent role of connective tissue growth factor in the development of liver fibrosis.
第一作者:
Keiko,Sakai
第一单位:
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
作者:
医学主题词
动物(Animals);四氯化碳(Carbon Tetrachloride);慢性病(Chronic Disease);胶原Ⅰ型(Collagen Type I);结缔组织生长因子(Connective Tissue Growth Factor);疾病模型, 动物(Disease Models, Animal);纤连蛋白类(Fibronectins);基因表达调控(Gene Expression Regulation);人类(Humans);肝(Liver);肝硬化(Liver Cirrhosis);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);RNA, 信使(RNA, Messenger);受体, 转化生长因子β(Receptors, Transforming Growth Factor beta);信号传导(Signal Transduction);转化生长因子β(Transforming Growth Factor beta);增量调节(Up-Regulation)
DOI
10.1016/j.ajpath.2014.06.009
PMID
25108224
发布时间
2025-05-29
基金项目
MR/K006312/1/MRC_/Medical Research Council/United Kingdom
R01 DK074538/DK/NIDDK NIH HHS/United States
DK074538/DK/NIDDK NIH HHS/United States
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