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首页> Proceedings of the National Academy of Sciences of the United States of America> Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.

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作者： André,Schütte ^[1] ; Anna,Ermund ^[1] ; Christoph,Becker-Pauly ^[2] ; Malin E V,Johansson ^[1] ; Ana M,Rodriguez-Pineiro ^[1] ; Fredrik,Bäckhed ^[3] ; Stefan,Müller ^[4] ; Daniel,Lottaz ^[5] ; Judith S,Bond ^[6] ; Gunnar C,Hansson ^[7]

作者单位： Departments of Medical Biochemistry and. ^[1] Unit for Degradomics of the Protease Web, Institute of Biochemistry, Christian Albrechts University, 24118 Kiel, Germany; ^[2] Molecular and Clinical Medicine, University of Gothenburg, 40530 Gothenburg, Sweden; ^[3] FACSlab, Institute of Pathology, and. ^[4] Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland; and. ^[5] Department of Biochemistry and Molecular Biology, Pennsylvania State University, Hershey, PA 17033. ^[6] Departments of Medical Biochemistry and gunnar.hansson@medkem.gu.se. ^[7]

关键词 gastrointestinal tract protease von Willebrand factor

主题词氨基酸序列(Amino Acid Sequence);动物(Animals);结合部位(Binding Sites);囊性纤维化跨膜传导调节因子(Cystic Fibrosis Transmembrane Conductance Regulator);无菌生物(Germ-Free Life);小肠(Intestine, Small);金属内肽酶类(Metalloendopeptidases);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交CFTR(Mice, Inbred CFTR);小鼠, 基因敲除(Mice, Knockout);分子序列数据(Molecular Sequence Data);黏蛋白2(Mucin-2);黏液(Mucus);蛋白质折叠(Protein Folding);蛋白质结构, 三级(Protein Structure, Tertiary);重组蛋白质类(Recombinant Proteins);序列同源性, 氨基酸(Sequence Homology, Amino Acid)

DOI 10.1073/pnas.1407597111

PMID 25114233

发布时间 2021-10-21

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2014年111卷34期

12396-401页

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2014年111卷34期

12396-401页

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