换一批Free radical derivatives formed from cyclooxygenase-catalyzed dihomo-γ-linolenic acid peroxidation can attenuate colon cancer cell growth and enhance 5-fluorouracil's cytotoxicity.
第一作者：
Yi,Xu
第一单位：
Department of Pharmaceutical Sciences, College of Pharmacy, Nursing and Allied Sciences, North Dakota State University, Fargo, ND 58108, USA.
作者：
关键词
5-FU, 5-Fluorouracil5-Fluorouracil8-HOA, 8-hydroxyoctanoic acidAA, arachidonic acidACN, acetonitrileCOX, cyclooxygenaseCOX-catalyzed PUFA peroxidationCell cycle and apoptosisColon cancer cell line HCA-7 colony 29D5D, delta-5 desaturaseDGLA, dihomo-γ-linoleic acidDGLA?s free radical derivativesDHA, docosahexaenoic acidEIC, extracted ion chromatogramEPA, eicosapentaenoic acidESR, electron spin resonanceGC, gas chromatographyHEX, 1-hexanolHOAc, glacial acetic acidHPLC/LC, high performance liquid chromatographyHTA, heptanoic acidLC/MS and ESR spin trappingMS, mass spectrometryPGs, prostaglandinsPI, propidium iodidePOBN, α-[4-pyridyl-1-oxide]-N-tert-butyl nitronePUFA, polyunsaturated fatty acidSPE, solid phase extractionTBS, Tris buffered salineTIC, total ion chromatogram
医学主题词
8,11,14-花生三烯酸(8,11,14-Eicosatrienoic Acid);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);生物催化(Biocatalysis);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);结肠肿瘤(Colonic Neoplasms);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);氟尿嘧啶(Fluorouracil);自由基(Free Radicals);人类(Humans);脂质过氧化作用(Lipid Peroxidation);前列腺素内过氧化物合酶类(Prostaglandin-Endoperoxide Synthases);构效关系(Structure-Activity Relationship)
DOI
10.1016/j.redox.2014.01.022
PMID
25114837
发布时间
2021-10-21
- 浏览62
Redox biology
2014年2卷
610-8页
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