Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity.

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作者： Maged,Henary ^[1] ; Lakshminarayana,Narayana ^[2] ; Shazia,Ahad ^[3] ; Sushma R,Gundala ^[4] ; Rao,Mukkavilli ^[5] ; Vibhuti,Sharma ^[4] ; Eric A,Owens ^[1] ; Yogesh,Yadav ^[2] ; Mulpuri,Nagaraju ^[1] ; Donald,Hamelberg ^[1] ; Vibha,Tandon ^[6] ; Dulal,Panda ^[3] ; Ritu,Aneja ^[7]

作者单位： Department of Chemistry and Biochemistry, Georgia State University, Petit Science Center, 100 Piedmont Ave., Atlanta, GA 30303, USA. ^[1] Department of Chemistry and Biochemistry, Georgia State University, Petit Science Center, 100 Piedmont Ave., Atlanta, GA 30303, USA; Department of Biology, Georgia State University, Petit Science Center, 100 Piedmont Ave., Atlanta, GA 30303, USA. ^[2] Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, India. ^[3] Department of Biology, Georgia State University, Petit Science Center, 100 Piedmont Ave., Atlanta, GA 30303, USA. ^[4] Advinus Therapeutics Limited, Bangalore, Karnataka, India. ^[5] Department of Chemistry, University of Delhi, India; Special Centre of Molecular Medicine, Jawaharlal Nehru University, Delhi, India. ^[6] Department of Biology, Georgia State University, Petit Science Center, 100 Piedmont Ave., Atlanta, GA 30303, USA. Electronic address: raneja@gsu.edu. ^[7]

关键词 Antiproliferative Noscapine Pharmacokinetics Tubulin binding Water solubility