Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease.

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作者： Catharina,Neudorfer ^[1] ; Karem,Shanab ^[2] ; Andreas,Jurik ^[3] ; Veronika,Schreiber ^[4] ; Carolina,Neudorfer ^[5] ; Chrysoula,Vraka ^[6] ; Eva,Schirmer ^[5] ; Wolfgang,Holzer ^[5] ; Gerhard,Ecker ^[3] ; Markus,Mitterhauser ^[7] ; Wolfgang,Wadsak ^[7] ; Helmut,Spreitzer ^[8]

作者单位： Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Waehringer Guertel 18-20, 1090 Vienna, Austria; University of Vienna, Faculty of Life Sciences, Department of Pharmaceutical Chemistry, Division of Drug Synthesis, Althanstraße 14, 1090 Vienna, Austria. Electronic address: catharina.neudorfer@gmail.com. ^[1] Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Waehringer Guertel 18-20, 1090 Vienna, Austria; University of Vienna, Faculty of Life Sciences, Department of Pharmaceutical Chemistry, Division of Drug Synthesis, Althanstraße 14, 1090 Vienna, Austria. ^[2] University of Vienna, Faculty of Life Sciences, Department of Pharmaceutical Chemistry Division of Drug Design and Medicinal Chemistry, Althanstraße 14, 1090 Vienna, Austria. ^[3] University of Vienna, Faculty of Life Sciences, Division of Clinical Pharmacy and Diagnostics, Althanstraße 14, 1090 Vienna, Austria. ^[4] University of Vienna, Faculty of Life Sciences, Department of Pharmaceutical Chemistry, Division of Drug Synthesis, Althanstraße 14, 1090 Vienna, Austria. ^[5] Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Waehringer Guertel 18-20, 1090 Vienna, Austria; University of Vienna, Department of Nutritional Sciences, Althanstraße 14, 1090 Vienna, Austria. ^[6] Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Waehringer Guertel 18-20, 1090 Vienna, Austria. ^[7] University of Vienna, Faculty of Life Sciences, Department of Pharmaceutical Chemistry, Division of Drug Synthesis, Althanstraße 14, 1090 Vienna, Austria. Electronic address: helmut.spreitzer@univie.ac.at. ^[8]

关键词 Alzheimer’s disease MAO-B Molecular imaging PET Pyrazoline derivatives