Morphine and oxycodone, but not fentanyl, exhibit antinociceptive effects mediated by G-protein inwardly rectifying potassium (GIRK) channels in an oxaliplatin-induced neuropathy rat model.

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第一作者： Tomoe,Kanbara

第一单位： Pain & Neurology, Discovery Research Laboratories, SHIONOGI Co., Ltd., 1-1, 3-chome, Futaba-cho, Toyonaka 561-0825, Osaka, Japan; Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

作者： Tomoe,Kanbara ^[1] ; Atsushi,Nakamura ^[1] ; Masahiro,Shibasaki ^[2] ; Tomohisa,Mori ^[2] ; Tsutomu,Suzuki ^[2] ; Gaku,Sakaguchi ^[3] ; Toshiyuki,Kanemasa ^[4]

作者单位： Pain & Neurology, Discovery Research Laboratories, SHIONOGI Co., Ltd., 1-1, 3-chome, Futaba-cho, Toyonaka 561-0825, Osaka, Japan; Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. ^[1] Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. ^[2] Pain & Neurology, Discovery Research Laboratories, SHIONOGI Co., Ltd., 1-1, 3-chome, Futaba-cho, Toyonaka 561-0825, Osaka, Japan. ^[3] Pain & Neurology, Discovery Research Laboratories, SHIONOGI Co., Ltd., 1-1, 3-chome, Futaba-cho, Toyonaka 561-0825, Osaka, Japan. Electronic address: toshiyuki.kanemasa@shionogi.co.jp. ^[4]

关键词 Antinociception G-protein inwardly rectifying K(+) channel MOR agonists Neuropathy Oxaliplatin