Poly (ADP-ribose) polymerase inhibition enhances trastuzumab antitumour activity in HER2 overexpressing breast cancer.

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作者： Jetzabel,García-Parra ^[1] ; Alba,Dalmases ^[1] ; Beatriz,Morancho ^[2] ; Oriol,Arpí ^[1] ; Silvia,Menendez ^[1] ; MohammadA,Sabbaghi ^[1] ; Sandra,Zazo ^[3] ; Cristina,Chamizo ^[3] ; Juan,Madoz ^[3] ; Pilar,Eroles ^[4] ; Sonia,Servitja ^[1] ; Ignasi,Tusquets ^[5] ; Jose,Yelamos ^[6] ; Ana,Lluch ^[7] ; Joaquin,Arribas ^[8] ; Federico,Rojo ^[9] ; Ana,Rovira ^[1] ; Joan,Albanell ^[10]

作者单位： Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Medical Oncology Department, Hospital del Mar, Barcelona, Spain. ^[1] Preclinical Research Program, Valld'Hebron Institute of Oncology (VHIO), Barcelona, Spain. ^[2] Pathology Department, IIS-Fundación Jiménez Díaz, Madrid, Spain. ^[3] Institute of Health Research INCLIVA, Valencia, Spain. ^[4] Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Medical Oncology Department, Hospital del Mar, Barcelona, Spain; Autonomous University of Barcelona, Spain. ^[5] Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Immunology Department, Hospital del Mar, Barcelona, Spain. ^[6] Oncology and Hematology Department, Hospital Clinico Universitario, Valencia, Spain; Valencia Central University, Spain. ^[7] Preclinical Research Program, Valld'Hebron Institute of Oncology (VHIO), Barcelona, Spain; Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain; Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain. ^[8] Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Pathology Department, IIS-Fundación Jiménez Díaz, Madrid, Spain; Pathology Department, Hospital del Mar, Barcelona, Spain. ^[9] Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Medical Oncology Department, Hospital del Mar, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain. Electronic address: jalbanell@hospitaldelmar.cat. ^[10]

关键词 Breast cancer HER2 Olaparib PARP Rucaparib Trastuzumab