A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding.

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第一作者： Annabelle,Lewis

第一单位： Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

作者： Annabelle,Lewis ^[1] ; Luke,Freeman-Mills ^[1] ; Elisa,de la Calle-Mustienes ^[2] ; Rosa María,Giráldez-Pérez ^[2] ; Hayley,Davis ^[1] ; Emma,Jaeger ^[1] ; Martin,Becker ^[3] ; Nina C,Hubner ^[4] ; Luan N,Nguyen ^[4] ; Jorge,Zeron-Medina ^[5] ; Gareth,Bond ^[5] ; Hendrik G,Stunnenberg ^[4] ; Jaime J,Carvajal ^[2] ; Jose Luis,Gomez-Skarmeta ^[2] ; Simon,Leedham ^[1] ; Ian,Tomlinson ^[6]

作者单位： Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. ^[1] Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Carretera de Utrera Km1, 41013 Sevilla, Spain. ^[2] Max Planck Institute for Psycholinguistics, Wundtlaan 1, 6525 XD Nijmegen, the Netherlands. ^[3] Department of Molecular Biology, Radboud Institute for Molecular Life Science, Geert Grooteplein 26/28, 6525 GA Nijmegen, the Netherlands. ^[4] Ludwig Institute for Cancer Research, Ltd., Nuffield Department of Clinical Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK. ^[5] Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: iant@well.ox.ac.uk. ^[6]