RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.-论文-万方医学网

第一作者： Marius,Dannappel

第一单位： 1] Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany [2].

作者： Marius,Dannappel ^[1] ; Katerina,Vlantis ^[1] ; Snehlata,Kumari ^[1] ; Apostolos,Polykratis ^[1] ; Chun,Kim ^[2] ; Laurens,Wachsmuth ^[2] ; Christina,Eftychi ^[2] ; Juan,Lin ^[2] ; Teresa,Corona ^[2] ; Nicole,Hermance ^[3] ; Matija,Zelic ^[3] ; Petra,Kirsch ^[4] ; Marijana,Basic ^[5] ; Andre,Bleich ^[5] ; Michelle,Kelliher ^[6] ; Manolis,Pasparakis ^[1]

作者单位： 1] Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany [2]. ^[1] Institute for Genetics, Centre for Molecular Medicine (CMMC), and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany. ^[2] Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. ^[3] Tierforschungszentrum, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany. ^[4] Institute for Laboratory Animal Science, Hannover Medical School, D-30625 Hannover, Germany. ^[5] 1] Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA [2]. ^[6]

医学主题词动物(Animals);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶8(Caspase 8);细胞存活(Cell Survival);上皮细胞(Epithelial Cells);Fas相关死亡结构域蛋白质(Fas-Associated Death Domain Protein);女(雌)性(Female);内环境稳定(Homeostasis);炎症(Inflammation);肠黏膜(Intestinal Mucosa);肠(Intestines);角蛋白细胞(Keratinocytes);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);髓样分化因子88(Myeloid Differentiation Factor 88);坏死(Necrosis);帕内特细胞(Paneth Cells);受体作用蛋白丝氨酸苏氨酸激酶类(Receptor-Interacting Protein Serine-Threonine Kinases);受体, 肿瘤坏死因子, Ⅰ型(Receptors, Tumor Necrosis Factor, Type I);皮肤(Skin)

DOI 10.1038/nature13608

PMID 25132550

发布时间 2021-10-21

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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.

Nature

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RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.

Nature

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Nature

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