首页> The Journal of biological chemistry> Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.

Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.

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第一作者： Xia,Liu

第一单位： From the Departments of Pathology and Laboratory Medicine and.

作者： Xia,Liu ^[1] ; Obiamaka,Obianyo ^[1] ; Chi Bun,Chan ^[1] ; Junjian,Huang ^[1] ; Shenghui,Xue ^[2] ; Jenny J,Yang ^[2] ; Fanxing,Zeng ^[3] ; Mark,Goodman ^[3] ; Keqiang,Ye ^[4]

作者单位： From the Departments of Pathology and Laboratory Medicine and. ^[1] the Departments of Chemistry and Biology, Center for Diagnostics and Therapeutics (CDT), Georgia State University, Atlanta, Georgia 30303. ^[2] Radiology and Imaging Sciences, Psychiatry, and Hematology and Oncology, Center for Systems Imaging, Wesley Woods Health Centers, Emory University School of Medicine, Atlanta, Georgia 30322 and. ^[3] From the Departments of Pathology and Laboratory Medicine and kye@emory.edu. ^[4]

关键词 7,8-Dihydroxyflavone Brain-Derived Neurotrophic Factor (BDNF)Cell Signaling Cell Surface Receptor Endocytosis Phosphorylation TrkB

医学主题词动物(Animals);生物物理学现象(Biophysical Phenomena);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);细胞, 培养的(Cells, Cultured);黄酮类(Flavones);人类(Humans);动力学(Kinetics);神经元(Neurons);蛋白质结合(Protein Binding);大鼠(Rats);受体, trkB(Receptor, trkB)

DOI 10.1074/jbc.M114.562561

PMID 25143381

发布时间 2021-10-21

基金项目

P30 NS055077/NS/NINDS NIH HHS/United States R01 DC010204/DC/NIDCD NIH HHS/United States R01 NS045627/NS/NINDS NIH HHS/United States NS045627/NS/NINDS NIH HHS/United States

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