Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities.

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作者： Mohammed,Alqarni ^[1] ; Kyaw Zeyar,Myint ^[2] ; Qin,Tong ^[1] ; Peng,Yang ^[1] ; Patrick,Bartlow ^[1] ; Lirong,Wang ^[1] ; Rentian,Feng ^[1] ; Xiang-Qun,Xie ^[3]

作者单位： Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, PA 15260, USA. ^[1] Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, PA 15260, USA; Joint Carnegie Mellon University-University of Pittsburgh Ph.D. Program, Department of Computational Biology and Structural Biology, School of Medicine, Pittsburgh, PA 15260, USA. ^[2] Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy, Pittsburgh, PA 15260, USA; Joint Carnegie Mellon University-University of Pittsburgh Ph.D. Program, Department of Computational Biology and Structural Biology, School of Medicine, Pittsburgh, PA 15260, USA; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: xix15@pitt.edu. ^[3]

关键词 Adenylyl cyclase (AC activity)Cannabinoid receptor subtype 2 (CB2)Cyclic adenosine monophosphate (cAMP)Molecular modeling Site-directed mutagenesis Time-resolved fluorescence resonance energy (TR-FRET) transfer